Molecular Epidemiology
Date:
22/03/2027 - 24/03/2027
Organised by:
University of Bristol Medical School Online Short Course Programme
Presenter(s):
Dr Matthew Suderman and Dr Hannah Elliott
Level:
Advanced (specialised prior knowledge)
Contact:
Bristol Medical School Short Course Programme
University of Bristol
short-course@bristol.ac.uk
+ 44 117 455 5987
www.bristol.ac.uk/medical-school-short-courses
Venue: Online
This course enables participants to develop skills for identifying the causes and consequences of molecular variation within population-based studies. Causes of molecular variation explored include genotype, developmental processes, exposures, phenotypes, and disease processes. Consequences examined include health outcomes such as disease onset, disease progression and response to therapy.
The course will be led by molecular epidemiologists in the MRC Integrative Epidemiology Unit at the University of Bristol. Their research utilises biological samples from a variety of established cohort resources and applies bioinformatic and statistical approaches for biomarker development and validation.
This course aims to provide an overview of epidemiological principles that are relevant to population-based molecular studies and provide participants with the knowledge and skills necessary to design, execute and interpret population-based molecular studies.
This course will cover:
- the various uses of high-throughput molecular data in epidemiology and medicine (including as an exposure, outcome, mediator, indicator and predictor);
- key considerations in the design of molecular studies (including choosing appropriate technologies and statistical analyses);
- practical analysis of molecular data;
- interpreting the biological function some of the most popular molecular data types (including DNA methylation, metabolite abundance, gene expression, protein abundance and genetics);
- methods for deriving and evaluating the performance of molecular biomarkers for indexing exposure and predicting health outcomes;
- causality of molecular phenotypes (including the importance of establishing causality to address certain research questions, examples of causal inference techniques, applying Mendelian randomization); and
- critical appraisal of the molecular epidemiological literature.
Cost:
£750
Website and registration:
Region:
South West
Keywords:
Big data, molecular epidemiology
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