Pharmacological Modelling
Date:
13/02/2012 - 16/02/2012
Organised by:
Lancaster University
Presenter:
Professor John Whitehead
Level:
Intermediate (some prior knowledge)
Contact:
psc@lancaster.ac.uk
Description:Pharmacological models are used to describe the pharmacokinetics and pharmacodynamics of drug administration. The former concerns how the drug becomes distributed within the body and the latter how drug concentrations are related to physiological effects. The way in which models are derived from simplified representations of the body, and approaches to the estimation of model parameters, will be described. More advanced hierarchical models and Bayesian methods for population pharmacokinetics will be discussed, and their fitting using PROC NLMIXED in SAS described. The course will also cover the design and analysis of phase I clinical trials in human volunteers designed to establish a maximum safe dose and to identify indications of therapeutic activity. In particular, modern designs for dose-escalation based on Bayesian procedures will be studied.
Practicals will provide an opportunity for participants to fit simple models to data, and to design and evaluate phase I dose-escalation studies.
Cost:
See website for details.
Website and registration:
Register for this course
Region:
North West
Keywords:
Quantitative Approaches (other)
Related publications and presentations from our eprints archive:
Quantitative Approaches (other)
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